Réaction #619234

ord-d8d44b52843e4c3db6e159e8c1e5ab13

Équation de réaction

CCOC(=O)C(C)Sc1cnc(NC(=O)N(C2CCCCCC2)C2CCCCC2)s1
[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester
C1CCCC(NC2CCCCC2)CC1
cycloheptyl-cyclohexylamine
CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester
→
O=C(O)CCSc1cnc(NC(=O)N(C2CCCCCC2)C2CCCCC2)s1
title compound
O=C(O)CCSc1cnc(NC(=O)N(C2CCCCCC2)C2CCCCC2)s1
3-[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid

Réactifs

CCOC(=O)C(C)Sc1cnc(NC(=O)N(C2CCCCCC2)C2CCCCC2)s1
[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester
C1CCCC(NC2CCCCC2)CC1
cycloheptyl-cyclohexylamine
CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreHydrolysis

Mode opératoire

[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester pre-pared as described in general procedure (A) using cycloheptyl-cyclohexylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: USRE045183E1uspto-grants-2014_10