Réaction #619153

ord-15ce8ff1d4f6422ea9acbf3e66143668

Équation de réaction

CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
sodium triacetoxyborohydride
O=Cc1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1
1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea
CC(=O)O
acetic acid
C1COCCN1
morpholine
→
O=C(Nc1ncc(CN2CCOCC2)s1)N(C1CCCCC1)C1CCCCC1
desired product
Rendement 34.4%
O=C(Nc1ncc(CN2CCOCC2)s1)N(C1CCCCC1)C1CCCCC1
1,1-Dicyclohexyl-3-(5-morpholin-4-ylmethyl-thiazol-2-yl)-urea
Rendement 34.4%

Réactifs

CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
sodium triacetoxyborohydride
O=Cc1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1
1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea
CC(=O)O
acetic acid
C1COCCN1
morpholine

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutrePrepared

Mode opératoire

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (100 mg, 0.30 mmol), acetic acid (18 μL, 0.30 mmol), morpholine (78 μL, 0.90 mmol) and sodium triacetoxyborohydride (70 mg, 0.33 mmol) to afford 42 mg (34%) of the desired product after purification.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: USRE045183E1uspto-grants-2014_10