Réaction #619152

Équation de réaction

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid benzyl ester

→

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid

Solvants

MeOH

Conditions de réaction

Traitement

1. 1
   Autreto degas the mixture
2. 2
   Autre(24 h)
3. 3
   FiltrationAfter filtering
4. 4
   Concentrationconcentration
5. 5
   Autrethe pure acid was obtained by trituration

Mode opératoire

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid benzyl ester (30 mg, 0.057 mmol) was combined with palladium on carbon (20 mg) in MeOH. Vacuum was applied to degas the mixture. The reaction was subjected to hydrogen and vigorous stirring until no ester could be detected (24 h). After filtering and concentration, the pure acid was obtained by trituration.

Source