Réaction #619119

ord-161fccc84bf84ac0b13d59920d434a0e

Équation de réaction

CCOC(=O)c1nc(NC(=O)N(C2CCCCC2)C2CCCCC2)sc1SC
2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid ethyl ester
CCOC(=O)c1nc(NC(=O)N(C2CCCCC2)C2CCCCC2)sc1SC#N
2-(3,3-dicyclohexyl-ureido)-5-thiocyanato-thiazole-4-carboxylic acid ethyl ester
CI
methyl iodide
CSc1sc(NC(=O)N(C2CCCCC2)C2CCCCC2)nc1C(=O)O
title compound
CSc1sc(NC(=O)N(C2CCCCC2)C2CCCCC2)nc1C(=O)O
2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreHydrolysis

Mode opératoire

2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid ethyl ester was pre-pared as described in general procedure (H) using 2-(3,3-dicyclohexyl-ureido)-5-thiocyanato-thiazole-4-carboxylic acid ethyl ester and methyl iodide. Hydrolysis using general procedure (F) gave the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: USRE045183E1uspto-grants-2014_10