Réaction #619117

Équation de réaction

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

→

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester

Rendement 47.7%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe content was degassed
2. 2
   FiltrationThe mixture was filtered through celite
3. 3
   Concentrationthe filtrate was concentrated
4. 4
   AutreThe residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1

Mode opératoire

To a solution of 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester (Example 257) (75 mg, 0.18 mmol) in methanol was added Pd/C (150 mg). The content was degassed and was placed under hydrogen atmosphere for 12 h. The mixture was filtered through celite, and the filtrate was concentrated. The residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1 to give 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester (35 mg) in 47% yield.

Source