Réaction #619103

ord-b49d9ec6afa049aeb5bf3dbc7d8a16ab

Équation de réaction

CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-Bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CCOC(=O)c1cnc(S)n1C
2-mercapto-3-methyl-3H-imidazole-4-carboxylic acid ethyl ester
→
CCOC(=O)c1cnc(Sc2cnc(NC(=O)N(C3CCCC3)C3CCC(C)CC3)s2)n1C
2-{2-[3-Cyclopentyl-3-(4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-3-methyl-3H-imidazole-4-carboxylic acid ethyl ester

Réactifs

CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-Bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CCOC(=O)c1cnc(S)n1C
2-mercapto-3-methyl-3H-imidazole-4-carboxylic acid ethyl ester

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutrePrepared

Mode opératoire

Prepared as described in general procedure (E) using 3-(5-bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea (Example 202) and 2-mercapto-3-methyl-3H-imidazole-4-carboxylic acid ethyl ester.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: USRE045183E1uspto-grants-2014_10