Réaction #619100

ord-54622b8d351c4a119a3643080c110268

Équation de réaction

CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-Bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
COC(=O)CS
methyl thioglycolate
→
COC(=O)CSc1cnc(NC(=O)N(C2CCCC2)C2CCC(C)CC2)s1
{2-[3-Cyclopentyl-3-(4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid methyl ester

Réactifs

CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-Bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
COC(=O)CS
methyl thioglycolate

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutrePrepared

Mode opératoire

Prepared as described in general procedure (D) using 3-(5-bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea (Example 202) and methyl thioglycolate.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: USRE045183E1uspto-grants-2014_10