Réaction #619083

Équation de réaction

Dicyclohexylamine

aminothiazole

carbonyldiimidazole

→

title product

1,1-Dicyclohexyl-3-thiazol 2 yl urea

Solvants

ethyl acetate

dichloromethane

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGthe reaction stirred overnight at room temperature
2. 2
   Lavagewashed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL)
3. 3
   Séchagedried over magnesium sulphate
4. 4
   Concentrationconcentrated in vacuo
5. 5
   Autrethe residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min)

Mode opératoire

To a solution of aminothiazole (50 mg, 0.5 mmol) in dichloromethane was added carbonyldiimidazole (81 mg, 0.5 mmol) and the solution stirred 2 h at room temperature. Dicyclohexylamine (1 eq) was then added and the reaction stirred overnight at room temperature. The reaction mixture is then diluted with ethyl acetate (8 mL), washed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL), dried over magnesium sulphate, concentrated in vacuo, and the residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min) to give the title product (52 mg).

Source