Réaction #61171

Équation de réaction

2,4-difluoronitrobenzene

piperidine

→

title compound

1-(5-Fluoro-2-nitro-phenyl)-piperidine

Solvants

EtOH

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in EtOAc (100 mL)
3. 3
   Lavagewashed with water (2×100 mL)
4. 4
   Séchagedried (Na2SO4)
5. 5
   Concentrationconcentrated in vacuo
6. 6
   AutrePurification by silica gel column chromatography

Mode opératoire

To a solution of 2,4-difluoronitrobenzene (2.09 g, 13.1 mmol) in EtOH (10 mL) at ambient temperature was added piperidine (3.35 g, 39.4 mmol) dropwise. The reaction was allowed to stir overnight and concentrated in vacuo. The residue was dissolved in EtOAc (100 mL), washed with water (2×100 mL), dried (Na2SO4) and concentrated in vacuo. Purification by silica gel column chromatography afforded 1.10 (37%) of the title compound as an oil. Mass spectrum (ESI, m/z): Calcd. for C11H13FN2O2, 225.1 (M+H), found 225.1.

Source