Réaction #610523

Équation de réaction

Coumarin

n-hexylamine

DBU

→

coumarin monoamine

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONmixed in bulk
2. 2
   AutreThe mixture was reacted in an oven
3. 3
   AutreThe resultant crude mixture was separated by preparative Thin Layer Chromatography (TLC) (eluent: ethylacetate/n-hexane=1/4 (vol./vol.))

Mode opératoire

Coumarin (0.3775 g, 2.583 mmol), 2.0 equimolar of n-hexylamine (0.5324 g, 5.261 mmol) and 0.1 equimolar of DBU (0.0418 g, 0.275 mmol) were added and mixed in bulk. The mixture was reacted in an oven and kept at 50° C. for 10 days. The resultant crude mixture was separated by preparative Thin Layer Chromatography (TLC) (eluent: ethylacetate/n-hexane=1/4 (vol./vol.)) to give corresponding coumarin monoamine (1:2) adduct (0.8287 g, 2.378 mmol, yield=92%).

Source