Réaction #607441

Équation de réaction

3′,5′-difluoroacetophenone

acetaldehyde

→

title compound

Rendement 40.0%

(−)-(S)-1-(3,5-difluorophenyl)ethanol

Rendement 40.0%

Solvants

THF

Conditions de réaction

Traitement

1. 1
   Températurecooled to −27° C. to −25° C.
2. 2
   TempératureThe reaction was maintained at this temperature for 17 h
3. 3
   Autreto reach room temperature
4. 4
   AutreThe solvent was then removed in vacuo
5. 5
   Autrethe resulting residue was partitioned between water (10 mL) and TBME (tert-butyl-methyl ether) (20 mL)
6. 6
   ExtractionThe aqueous phase was extracted again with TBME (20 mL)
7. 7
   LavageThe organic layer was washed with an aqueous 2 N NaOH solution (20 mL), brine (20 mL)
8. 8
   Séchagedried over anhydrous Na2SO4
9. 9
   Filtrationfiltered
10. 10
    AutreThe solvent was removed in vacuo
11. 11
    Autreto give a residue, which
12. 12
    Autrewas purified by two subsequent column chromatographic steps

Mode opératoire

To a stirred solution of (−)-DIP-Cl ((−)-diisopinocampheylboron chloride) (2.67 g, 8.33 mmol, 1.3 eq) in THF (20 mL) kept under inert atmosphere (Ar) and cooled to −27° C. to −25° C., 3′,5′-difluoroacetophenone (1.00 g, 6.40 mmol) was added drop wise over 2 min. The reaction was maintained at this temperature for 17 h. The reaction mixture was then treated with acetaldehyde (0.44 mL, 7.69 mmol, 1.2 eq). Thereafter, the temperature was allowed to reach room temperature and the reaction mixture was stirred at for 7 h. The solvent was then removed in vacuo and the resulting residue was partitioned between water (10 mL) and TBME (tert-butyl-methyl ether) (20 mL). The aqueous phase was extracted again with TBME (20 mL). The organic layer was washed with an aqueous 2 N NaOH solution (20 mL), brine (20 mL), dried over anhydrous Na2SO4 and filtered. The solvent was removed in vacuo to give a residue, which was purified by two subsequent column chromatographic steps: First by normal phase chromatography (silica gel, heptane/ethyl acetate, v/v=1/0-9/1) followed by a reversed phase chromatography (90 C18-silica gel, acetonitrile for the second one). This gave the title compound (0.40 g, 40%) as a colorless oil with a specific rotation of [α]25D=−26.66 (c=1.054 g/100 mL, CH2Cl2, 589 nm).

Source