Réaction #60423

Équation de réaction

1-[2-(4,4-diethylcyclohex-1-enyl)-5-methoxyphenyl]-4-(tetrahydropyran-4-ylmethyl)piperazine hydrochloride

→

title compound

Rendement 99.6%

1-[2-(4,4-Diethylcyclohexyl)-5-methoxyphenyl]-4-(tetrahydropyran-4-ylmethyl)piperazine hydrochloride

Rendement 99.6%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction mixture was passed through Celite for filtration
2. 2
   Concentrationthe filtrate was concentrated under reduced pressure
3. 3
   LavageThe residual solid was washed with diethyl ether
4. 4
   FiltrationIt was then filtered

Mode opératoire

Ten percent of palladium on carbon (100 mg, wet) was added to a solution of 1-[2-(4,4-diethylcyclohex-1-enyl)-5-methoxyphenyl]-4-(tetrahydropyran-4-ylmethyl)piperazine hydrochloride (34 mg) prepared in Example (6g) in methanol (5 mL), and the mixture was stirred for 13 hours under a hydrogen atmosphere at atmospheric pressure and room temperature. The reaction mixture was passed through Celite for filtration, and the filtrate was concentrated under reduced pressure. The residual solid was washed with diethyl ether. It was then filtered to give 34 mg of the title compound as a light yellow solid.

Source