Réaction #60106

Équation de réaction

2,6-dichloro-3-acetamidopyridine

pyridine

trifluoroacetic anhydride

→

product

Rendement 90.0%

2,6-dichloropyridine-3-carbonitrile

Rendement 90.0%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added
2. 2
   Concentrationconcentrated under reduced pressure
3. 3
   AutreThe crude product was purified by flash chromatography
4. 4
   Lavageeluting with 85% hexane

Mode opératoire

To a mixture of 2,6-dichloro-3-acetamidopyridine (6.3 g, 55% pure) and pyridine (4.93 ml, 61 mmole) in dichloromethane (100 ml), trifluoroacetic anhydride (4.23 ml, 30 mmole) was added. The reaction mixture was stirred at room temperature overnight and concentrated under reduced pressure. The crude product was purified by flash chromatography, eluting with 85% hexane: 15% ethyl acetate to give a pale yellow product (1.77 g, 90%).

Source