Réaction #597782

Équation de réaction

7-fluoro-2,2-dimethyl-3,4-dihydro-2H-chromene-4-carboxylic acid

TMSCHN2

→

title compound

Rendement 75.6%

methyl 7-fluoro-2,2-dimethyl-3,4-dihydro-2H-chromene-4-carboxylate

Rendement 75.6%

Solvants

CH2Cl2

MeOH

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONAfter the addition
2. 2
   Concentrationthe reaction was concentrated
3. 3
   Lavagethe product eluted

Mode opératoire

To 7-fluoro-2,2-dimethyl-3,4-dihydro-2H-chromene-4-carboxylic acid (0.280 g, 1.25 mmol) in CH2Cl2 (5 mL) and MeOH (1 mL) was added TMSCHN2 (0.937 mL, 1.87 mmol) dropwise. After the addition, the reaction was concentrated, loaded onto silica gel, and the product eluted using a gradient of 5% ethyl acetate/hexanes to 40% ethyl acetate/hexanes to provide the title compound (0.225 g, 75.6% yield).

Source