Réaction #5973

Équation de réaction

2-methoxy-4-amino-5-chlorobenzoic acid

HCl

methanol

→

methyl 2-methoxy-4-amino-5-chlorobenzoate

Conditions de réaction

Traitement

1. 1
   workup.DISSOLUTIONdissolves
2. 2
   Autrethe solvent removed
3. 3
   workup.ADDITIONether added
4. 4
   Filtrationfiltered
5. 5
   Séchagedried over magnesium sulfate
6. 6
   Autreevaporated to dryness

Mode opératoire

To a solution of 50g of 2-methoxy-4-amino-5-chlorobenzoic acid in 500 ml of methanol is added HCl gas until all the material dissolves. Stirring is continued overnight, the solvent removed, ether added, filtered, dried over magnesium sulfate and evaporated to dryness to obtain methyl 2-methoxy-4-amino-5-chlorobenzoate which is used directly in the next step.

Source