Réaction #596045

ord-658f6c861d914f0982b2fa342e7c6f56

Équation de réaction

COc1cc(Cl)c(C(N)=O)cc1CNC(=O)C(F)(F)F
5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzamide
O=C(Cl)C(=O)Cl
oxalyl chloride
→
COc1cc(Cl)c(C(=O)N=C=O)cc1CNC(=O)C(F)(F)F
desired product
COc1cc(Cl)c(C(=O)N=C=O)cc1CNC(=O)C(F)(F)F
5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate

Réactifs

COc1cc(Cl)c(C(N)=O)cc1CNC(=O)C(F)(F)F
5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzamide
O=C(Cl)C(=O)Cl
oxalyl chloride

Réactifs

Aucun

Solvants

ClCCCl
EDC

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreThe title compound was prepared

Mode opératoire

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzamide (1.0 g, 3.6 mmol), oxalyl chloride (1.0 mL) and EDC (10 mL) to afford 0.750 g of the desired product.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US09096545B2uspto-grants-2015_08