Réaction #59443

Équation de réaction

piperidine

Malononitrile

2-fluorobenzaldehyde

→

title material

Rendement 28.3%

2-(2-Fluoro-benzylidene)-malononitrile

Rendement 28.3%

Solvants

iso-propyl acetate

Conditions de réaction

Traitement

1. 1
   Autrewere placed in a vessel
2. 2
   Autrewhich was irradiated in a 300 W single mode microwave for 15 seconds
3. 3
   Filtrationfiltered
4. 4
   Autreevaporated
5. 5
   Filtrationfiltered through a pad of Magnasol
6. 6
   Autreevaporated
7. 7
   Autrerecrystallized from ethanol

Mode opératoire

Malononitrile (3.303 g, 50 mmol), 2-fluorobenzaldehyde (6.205 g, 50 mmol), 1 g of molecular sieves, and 500 mg of a resin bound piperidine (described in Tetrahedron Lett., 1999, 40, 7031-33) were placed in a vessel which was irradiated in a 300 W single mode microwave for 15 seconds. The reaction mixture was taken up in iso-propyl acetate, filtered, evaporated, taken up in dichloromethane, filtered through a pad of Magnasol, evaporated, and recrystallized from ethanol to yield 2.435 g of the title material as a crystalline solid,

Source