Réaction #5934

Équation de réaction

ethyl acetate

(±)-2-(4-chlorophenyl)-3,4-dihydro-2H-1,4-benzothiazine

(S)-N-(2-naphthalenesulfonyl)prolyl chloride

→

(R)-2-(4-chlorophenyl)-4-[(S)-N-(2-naphthalenesulfonyl)prolyl]-3,4-dihydro-2H-1,4-benzothiazine

Rendement 51.5%

Solvants

pyridine

Conditions de réaction

Traitement

1. 1
   Lavagethe mixture is washed with 5 % hydrochloric acid, water, aqueous sodium hydrogen carbonate solution, water and saline in this order
2. 2
   Autrethe ethyl acetate layer is separated
3. 3
   Séchagedried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled
5. 5
   Autreto remove the solvent
6. 6
   LavageFrom the fraction eluted first there

Mode opératoire

To a solution of (±)-2-(4-chlorophenyl)-3,4-dihydro-2H-1,4-benzothiazine (10.01 g, 0.038 mole) in pyridine (150 ml) is added (S)-N-(2-naphthalenesulfonyl)prolyl chloride (18.57 g, 0.057 mole), and the mixture is stirred at room temperature for 4 hours. To the reaction mixture is added ethyl acetate, and the mixture is washed with 5 % hydrochloric acid, water, aqueous sodium hydrogen carbonate solution, water and saline in this order, and the ethyl acetate layer is separated, dried over sodium sulfate and distilled to remove the solvent. The resulting caramel is subjected to silica gel column chromatography (hexane:ethyl acetate=5:1 - 3:1). From the fraction eluted first there is obtained (R)-2-(4-chlorophenyl)-4-[(S)-N-(2-naphthalenesulfonyl)prolyl]-3,4-dihydro-2H-1,4-benzothiazine (10.75 g, 51 %) as crystals. M.p. 147°-151° C.

Source