Réaction #592255

Équation de réaction

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide

sodium trimethylsilanolate

→

title compound

Rendement 27.0%

6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid

Rendement 27.0%

Solvants

DCE

Conditions de réaction

Traitement

1. 1
   Concentrationthe mixture was concentrated in vacuo
2. 2
   Autrepurified by prep

Mode opératoire

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspensed in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound in 27% yield.

Source