Réaction #59072

Équation de réaction

3-(tert-butyl)phenylamine

sodium bicarbonate

thiophosgene

→

3-(tert-butyl)benzenisothiocyanate

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   Autrewas brought to ambient temperature
2. 2
   Concentrationconcentrated
3. 3
   Autrepartitioned between ethyl acetate and water
4. 4
   SéchageThe organic layer was dried with sodium bicarbonate and sodium sulfate
5. 5
   Concentrationconcentrated

Mode opératoire

To 3-(tert-butyl)phenylamine in acetone at 0° C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq). The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water. The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 3-(tert-butyl)benzenisothiocyanate. MS: MH+=192.

Source