Réaction #59025

Équation de réaction

Water

Ethyl bromoacetate

5-bromo-2-hydroxyacetophenone

potassium carbonate

→

ethyl (2-acetyl-4-bromophenoxy)acetate

Solvants

ethyl acetate

N,N-dimethylformamide

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGthe mixture was stirred at that temperature overnight
2. 2
   AutreThe organic layer was separated
3. 3
   Lavagewashed with water and brine
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   AutreThe solvent was evaporated under reduced pressure

Mode opératoire

Ethyl bromoacetate (0.62 mL) was added to a mixture of 5-bromo-2-hydroxyacetophenone (1.0 g) and potassium carbonate (0.96 g) in N,N-dimethylformamide (10 mL) at room temperature with stirring, and the mixture was stirred at that temperature overnight. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford ethyl (2-acetyl-4-bromophenoxy)acetate as a crude product.

Source