Réaction #589028

Équation de réaction

(4—Nitrophenoxy)-acetic acid-2-hydroxyethyl ester

(4-Nitrophenoxy)-acetic acid-2-hydroxy-ethyl ester

→

(4-Amino-phenoxy)-acetic acid 2-hydroxy-ethyl ester

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   AutreCatalyst was removed by filtration
2. 2
   workup.DISTILLATIONthe ethyl acetate distilled off
3. 3
   workup.ADDITIONhexane added
4. 4
   FiltrationThe solid product was filtered
5. 5
   Autredried
6. 6
   Autreto give pure 28 (0.2 g 22.8%) as a brown powder with an m.p. between 104-106.3° C.

Mode opératoire

(4—Nitrophenoxy)-acetic acid-2-hydroxyethyl ester 23 (1 g, 4.15 mmol) was dissolved in ethyl acetate in a pressure vessel. Palladium on carbon (5%, 0.5 g) was added and the mixture stirred under an atmosphere of hydrogen (0.5 kg) for one hour. Catalyst was removed by filtration, the ethyl acetate distilled off and hexane added. The solid product was filtered and dried to give pure 28 (0.2 g 22.8%) as a brown powder with an m.p. between 104-106.3° C.

Source