Réaction #5890

ord-c1cccb7f4ab14334a9142cd6bd51341b

Équation de réaction

CC1CCN(c2cc3nc(C(C)(C)C)sc3cc2N=C=S)CC1
2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole
CC(=O)N1CCNCC1
1-acetyl-piperazine
→
CC(=O)N1CCN(C(=S)Nc2cc3sc(C(C)(C)C)nc3cc2N2CCC(C)CC2)CC1
6-[(4-acetyl-piperazin-1-yl)thiocarbonylamino]-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole

Réactifs

CC1CCN(c2cc3nc(C(C)(C)C)sc3cc2N=C=S)CC1
2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole
CC(=O)N1CCNCC1
1-acetyl-piperazine

Réactifs

Aucun

Solvants

ClC(Cl)Cl
chloroform

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Autrethe product triturated with petroleum ether

Mode opératoire

A solution of 2.0 g of 2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole and 0.78 g of 1-acetyl-piperazine in 30 ml of chloroform is stirred for 30 minutes and the product triturated with petroleum ether to obtain 6-[(4-acetyl-piperazin-1-yl)thiocarbonylamino]-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole, melting at 187°-190°.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05246927uspto-grants-1993_09