Réaction #587763

Équation de réaction

dibenzofuran

trioxane

bromide

→

bromide

2-Bromomethyl-dibenzofuran

Solvants

acetic acid

HBr

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in CH2Cl2
3. 3
   Lavagewashed with water
4. 4
   Séchagedried over Na2SO4
5. 5
   Autreevaporated

Mode opératoire

A mixture of dibenzofuran (93.5 g, 0.557 M), trioxane (20 g, 0.222 M) and myrystyltrimethylammonium bromide (6.2 g, 18.5 mmol) in 1 L acetic acid and 135 mL of 48% HBr was stirred at 50-60° C. for 28 h, then concentrated; the residue was dissolved in CH2Cl2, washed with water, dried over Na2SO4, evaporated to give the crude bromide 1a. Compound 1a was used without further purification in the next step.

Source