Réaction #586136

Équation de réaction

sodium bicarbonate

[3-(2,4-dichlorophenyl)phenyl] isopropyl sulfide

m-chloroperbenzoic acid

→

[3-(2,4-dichlorophenyl)phenyl] isopropyl sulfoxide

Rendement 85.0%

Solvants

chloroform

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGthe reaction mixture was stirred for 2 hours
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature for another 12 hours
3. 3
   LavageThe chloroform layer was washed with 5% aqueous sodium sulfite and water
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
6. 6
   AutrePurification of the residue by silica gel column chromatography

Mode opératoire

To 1.0 g (3.4 mmol) of [3-(2,4-dichlorophenyl)phenyl] isopropyl sulfide in 50 ml of chloroform, 0.7 g (4.1 mmol) of m-chloroperbenzoic acid was added at 0° C. with stirring, and the reaction mixture was stirred for 2 hours. The reaction mixture was stirred at room temperature for another 12 hours, and 5% aqueous sodium bicarbonate was added for separation. The chloroform layer was washed with 5% aqueous sodium sulfite and water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. Purification of the residue by silica gel column chromatography afforded 0.9 g of [3-(2,4-dichlorophenyl)phenyl] isopropyl sulfoxide (yield 85.0%) as a colorless dough (nD20 1.6169).

Source