Réaction #586100

Équation de réaction

product

2-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propene

hydrogen

→

2-(2-aminophenyl)-3-(trimethylsilyl)-propane

Rendement 88.0%

Solvants

tetrahydrofurane

Conditions de réaction

Traitement

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Autreafter evaporation of the solvent
3. 3
   Autrethe product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane)

Mode opératoire

The reaction product of step A [7.2 g] was hydrogenated in tetrahydrofurane over palladium on charcoal at atmospheric pressure and room temperature until the uptake of hydrogen ceased. The catalyst was filtered off and, after evaporation of the solvent, the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane) to yield 2-(2-aminophenyl)-3-(trimethylsilyl)-propane [4.7 g; 88% purity according to NMR]. This product was used in the next step without further purification.

Source