Réaction #585320

Équation de réaction

water

3,5-dimethylbenzenethiol

potassium carbonate

Iodomethane

→

crude product

Rendement 88.0%

1,3-Dimethyl-5-methylsulfanyl-benzene

Rendement 88.0%

Solvants

dimethylsulfoxide

Conditions de réaction

Traitement

1. 1
   Extractionthe product is extracted with ether
2. 2
   Lavagewashed with water
3. 3
   Séchagedried over sodium sulfate
4. 4
   Concentrationconcentrated in vacuo

Mode opératoire

10.0 g (0.072 mol) of 3,5-dimethylbenzenethiol, 9.95 g (0.072 mol) of potassium carbonate and 0.46 g (1.4 mmol) of tetrabutylammonium bromide are suspended in 20 ml of dimethylsulfoxide under argon. Iodomethane (10.2 g, 0.072 mol) is added dropwise, and the mixture is stirred 16 h at ambient temperature. After pouring the mixture into water, the product is extracted with ether, washed with water, dried over sodium sulfate and concentrated in vacuo. The crude product 9.6 g (0.063 mol; 88%) is obtained as a slightly yellow oil, and is used for the next step without further purification.

Source