Réaction #5848

ord-bae6517f0d0c4e2b88dc16d1d8fd4fb6

Équation de réaction

Nc1cccc(O)c1
m-Aminophenol
O=C(O)c1ccc(O)cc1C(=O)O
4-hydroxyphthalic acid
→
O=C1c2ccc(O)cc2C(=O)N1c1cccc(O)c1
pale yellow powder
Rendement 80.5%
O=C1c2ccc(O)cc2C(=O)N1c1cccc(O)c1
N-(3-Hydroxyphenyl)-4-hydroxyphthalimide
Rendement 80.5%

Réactifs

Nc1cccc(O)c1
m-Aminophenol
O=C(O)c1ccc(O)cc1C(=O)O
4-hydroxyphthalic acid

Réactifs

Aucun

Solvants

CC(=O)O
acetic acid

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Autreto react
  2. 2
    AutreThe product (21.6 g, 91%), collected as a tan solid
  3. 3
    Autreis recrystallized from methanol

Mode opératoire

m-Aminophenol(13.23 g, 0.12 mol) and 4-hydroxyphthalic acid (16.98 g, 0.09 mol) are allowed to react in refluxing acetic acid as described above. The product (21.6 g, 91%), collected as a tan solid, is recrystallized from methanol to give 18.5 g of pale yellow powder [mp 270° C. differential scanning calorimetry] having the following structure: ##STR7##

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05246751uspto-grants-1993_09