Réaction #582539

Équation de réaction

formamide

2-amino-3-bromo-5-chlorobenzoic acid

→

8-Bromo-6-chloro-4(3H) quinazolinone

Conditions de réaction

Traitement

1. 1
   Températureat reflux overnight
2. 2
   TempératureThe mixture was cooled
3. 3
   Autrequenched with water
4. 4
   AutreThe solid that formed
5. 5
   Lavagewas washed with acetonitrile, 6.7 g crude (65%)

Mode opératoire

8-Bromo-6-chloro-4(3H) quinazolinone was prepared from 2-amino-3-bromo-5-chlorobenzoic acid (10 g, 40 mmol). The acid was heated in excess formamide (50 mL) at reflux overnight. The mixture was cooled and quenched with water. The solid that formed was washed with acetonitrile, 6.7 g crude (65%); MS: 260.8 (M+H)+

Source