Réaction #582510

ord-f7708f43148745cca8ced0dff432cb95

Équation de réaction

[Na+].[OH-]
sodium hydroxide
[Cl-].[NH4+]
ammonium chloride
O=S(=O)(Cl)c1c(F)c(F)c(F)c(F)c1F
pentafluorobenzenesulfonyl chloride
→
NS(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
pentafluorobenzenesulfonamide

Réactifs

[Na+].[OH-]
sodium hydroxide
[Cl-].[NH4+]
ammonium chloride
O=S(=O)(Cl)c1c(F)c(F)c(F)c(F)c1F
pentafluorobenzenesulfonyl chloride

Réactifs

Aucun

Solvants

CC(C)=O
acetone

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    workup.ADDITIONDuring addition, pH
  2. 2
    FiltrationPrecipitated product was filtered
  3. 3
    Autrerecrystallized from toluene

Mode opératoire

To an aqueous solution of ammonium chloride was added dropwise an acetone solution of pentafluorobenzenesulfonyl chloride at room temperature. During addition, pH was adjusted to 7 by an aqueous sodium hydroxide solution. Precipitated product was filtered and recrystallized from toluene to give pentafluorobenzenesulfonamide. The structure was confirmed by 1H-NMR, 19F-NMR and IR.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06939646B2uspto-grants-2005_09