Réaction #58108

Équation de réaction

5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one

1-(3,5-difluoro-benzyl)-cyclopropylamine

trifluoroacetate

→

8-{2-[1-(3,5-difluoro-benzyl)-cyclopropylamino]-1-hydroxy-ethyl}-5-hydroxy-4H-benzo[1,4]oxazin-3-one

Conditions de réaction

Traitement

1. 1
   AutrePrepared

Mode opératoire

Prepared according to general method 3 from 329 mg (1 mmol) 5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 183 mg (1 mmol) 1-(3,5-difluoro-benzyl)-cyclopropylamine. Yield: 66 mg (13%, trifluoroacetate); mass spectroscopy: [M+H]+=391.

Source