Réaction #57823

Équation de réaction

4-bromo-3-fluoro-benzenesulfonyl chloride

(2-amino-5-chloro-phenyl)-(pyridin-3-yl)-methanone

→

title compound

4-Bromo-N-[4-chloro-2-(pyridine-3-carbonyl)-phenyl]-3-fluoro-benzenesulfonamide

Solvants

pyridine

Conditions de réaction

Traitement

1. 1
   AutrePurification with silica chromatography
2. 2
   Lavageeluted with dichlorometane

Mode opératoire

The title compound was prepared according to the general procedures for the synthesis of N-Aryl-benzenesulfonamides previously described using (2-amino-5-chloro-phenyl)-(pyridin-3-yl)-methanone 2 g (8.7 mmol) and 4-bromo-3-fluoro-benzenesulfonyl chloride 2.35 g (8.77 mmol) in 15 ml pyridine. Purification with silica chromatography eluted with dichlorometane:10-ethyl acetate gave a yellow powder.

Source