Réaction #57809

Équation de réaction

rac-2,2′-bis (diphenylphosphino)-1,1′-binaphthyl

4-Bromo-N-[4-chloro-2-(pyridine-4-carbonyl)-phenyl]-benzenesulfonamide

potassium phosphate tribasic monohydrate

pyrrolidine

→

title compound

N-[4-chloro-2-(pyridine-4-carbonyl)-phenyl]-4-pyrrolidin-1-yl-benzenesulfonamide

Solvants

dioxane

Conditions de réaction

Traitement

1. 1
   AutreThe title compound was prepared

Mode opératoire

The title compound was prepared according to the general procedure for the synthesis of heterocyclyl and heteroaryl substituted phenylsulfonyl derivatives previously described, using 4-Bromo-N-[4-chloro-2-(pyridine-4-carbonyl)-phenyl]-benzenesulfonamide 0.3 g (0.66 mmol), potassium phosphate tribasic monohydrate 0.91 g (3.96 mmol), rac-2,2′-bis (diphenylphosphino)-1,1′-binaphthyl 0.12 g (0.198 mmol), pyrrolidine 0.23 g (3.3 mmol) and Pd (dba)3 60 mg (0.066 mmol) in 6 ml dioxane, yielding title compound after HPLC purification.: LC-MSD, m/z for C22H20ClN3O3S [M+H]+: 442.1

Source