Réaction #577469

Équation de réaction

( D1 )

3-Methyl-5-nitroisoquinoline

→

product

Rendement 76.1%

3-Methyl-5-aminoisoquinoline

Rendement 76.1%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Concentrationthe filtrate concentrated under reduced pressure

Mode opératoire

A solution of (D1) (1 g, 5.3 mM) and 10% palladium on charcoal (0.15 g) in methanol (40 ml) was hydrogenated at atmospheric pressure for 1 h. The catalyst was filtered off and the filtrate concentrated under reduced pressure to afford the product as a grey solid (0.64 g).

Source