Réaction #577213

Équation de réaction

4-cyano-4′-hydroxybiphenyl

bromide

potassium carbonate

butanone

→

4-allyloxy-4′-cyanobiphenyl

Solvants

Water

Conditions de réaction

Traitement

1. 1
   AutreA reaction mixture obtained
2. 2
   Températurewas refluxed for 7 hours
3. 3
   Autrewas then separated
4. 4
   LavageAn organic layer was washed with water
5. 5
   Séchagedried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off
7. 7
   Autreto obtain a residue, which
8. 8
   Autrewas purified by silica gel column chromatography
9. 9
   Autresubjected to recrystallization from ethanol

Mode opératoire

A reaction mixture obtained by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of ally bromide and 25 g of potassium carbonate to 250 mL of butanone was refluxed for 7 hours. Water was added to the reaction mixture, which was then separated. An organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain a residue, which was purified by silica gel column chromatography using toluene as an elusion solvent and then subjected to recrystallization from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

Source