Réaction #572486

Équation de réaction

2-naphthol

8-chloro-1-octanol

potassium carbonate

dimethylformamide

→

title compound

8-(2-naphthyloxy)-1-octanol

Solvants

ether

Water

Conditions de réaction

Traitement

1. 1
   LavageThe a solution was washed with aqueous potassium hydroxide
2. 2
   Autredried
3. 3
   Autreevaporated
4. 4
   AutreThe residue was chromatographed on silica gel
5. 5
   Lavageeluting with 95:5 dichloromethane
6. 6
   Autremethanol, and the product so obtained
7. 7
   Autrewas crystallized from hexane

Mode opératoire

A mixture of 2-naphthol (28.8 g), 8-chloro-1-octanol (32.8 g), potassium carbonate (40 g) and dimethylformamide (200 ml) was stirred at 60°-65° for 7 days. Water and ether were then added. The a solution was washed with aqueous potassium hydroxide, dried and evaporated. The residue was chromatographed on silica gel, eluting with 95:5 dichloromethane:methanol, and the product so obtained was crystallized from hexane, to give the title compound, mp 67°-9°.

Source