Réaction #57046

Équation de réaction

2,2-Dimethyl-hexanoic acid

(trimethylsilyl)diazomethane

→

ester

Rendement 100.4%

2,2-dimethyl-hexanoic acid methyl ester

Rendement 100.4%

Solvants

ether

Conditions de réaction

Traitement

1. 1
   Autreether was evaporated
2. 2
   workup.DISTILLATIONFractional distillation of the residue

Mode opératoire

To a solution of 2,2-Dimethyl-hexanoic acid (10.15 g, 0.07 mol) in ether (150 mL) was added (trimethylsilyl)diazomethane (46 ml, 2M in hexanes, 0.092 mol) drop wise. The mixture was stirred for 3 h, and ether was evaporated without applying reduced pressure. Fractional distillation of the residue provided the title ester 11.12 g (b.p. 90-95° C./1 mmHg). 1H NMR (CDCl3): δ 0.85 (t, J=7.0 Hz, 3H), 1.1-1.2 (m, 2H), 1.13 (s, 6H), 1.21-1.31 (m, 2H), 1.44-1.51 (m, 2H), 3.72 (s, 3H).

Source