Réaction #56918

Équation de réaction

4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

→

4-(5-bromo-2-butoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

Rendement 51.0%

Solvants

butan-1-ol

Conditions de réaction

Mode opératoire

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and butan-1-ol provided 4-(5-bromo-2-butoxy-phenyl)-6-chloro-pyrimidin-2-ylamine (51% yield).

Source