Réaction #5675

Équation de réaction

5-dimethylamino-2,3,4,5-tetrahydro-1H-benzazepine

potassium carbonate

p-nitrobenzoyl chloride

→

5-dimethylamino-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine

Rendement 97.1%

Solvants

water

acetone

water

Conditions de réaction

Traitement

1. 1
   Températurecooling
2. 2
   workup.STIRRINGthe mixture is stirred at room temperature overnight
3. 3
   Filtrationthe precipitated crystals are collected by filtration
4. 4
   Autredried

Mode opératoire

To a solution of 5-dimethylamino-2,3,4,5-tetrahydro-1H-benzazepine (50 g) in a mixture of acetone (400 ml) and water (200 ml) is added potassium carbonate (38.8 g), and thereto is added p-nitrobenzoyl chloride (40 g) with stirring under ice-cooling, and the mixture is stirred at room temperature overnight. To the reaction mixture is added an appropriate amount of water, and the precipitated crystals are collected by filtration and dried to give 5-dimethylamino-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine (71 g) as pale yellow powder, mp. 139°-142° C.

Source