Réaction #5674

Équation de réaction

oxazolidinone

diethyl bromomalonate

potassium carbonate

acetone

→

1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester

Conditions de réaction

Traitement

1. 1
   Filtrationfiltered
2. 2
   Lavagewashed with acetone
3. 3
   Autreevaporated to a brown oil
4. 4
   AutreThe oil is purified by flash chromatography
5. 5
   Lavageeluting with 5 percent acetone in toluene
6. 6
   Autreevaporated

Mode opératoire

A mixture of 240 mg of the above oxazolidinone, 234 mg of diethyl bromomalonate, 450 mg of anhydrous potassium carbonate and 10 ml of acetone is stirred overnight, filtered, washed with acetone and evaporated to a brown oil. The oil is purified by flash chromatography, eluting with 5 percent acetone in toluene. The pure fractions are combined and evaporated giving 237 mg of (R,R)-5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester as a colorless oil.

Source