Réaction #56518

Équation de réaction

9-hydroxy-1-oxo-1H-naphtho[2,1-b]pyran-2-carboxaldehyde acetate

hydroxylamine hydrochloride

sodium formate

→

9-Hydroxy-1-oxo-1H-naphtho[2,1-b]pyran-2-carbonitrile

Solvants

formic acid

Conditions de réaction

Traitement

1. 1
   Températureis refluxed for 30 hrs
2. 2
   AutreThe product crystallize
3. 3
   Températureon cooling
4. 4
   Filtrationis filtered
5. 5
   Lavagewashed with acetone

Mode opératoire

A mixture of 9-hydroxy-1-oxo-1H-naphtho[2,1-b]pyran-2-carboxaldehyde acetate (1 mm), hydroxylamine hydrochloride (1.3 mm) and sodium formate (2 mm) is refluxed for 30 hrs. in formic acid (3 parts). The product crystallize on cooling, is filtered and washed with acetone. The dry crystals are light beige, m.p. 289°-92° C.

Source