Réaction #56388

Équation de réaction

2-cyclopropylamino-4,6-dichloro-s-triazine

dioxane

ammonia

→

2-cyclopropylamino-4-chloro-6-amino-s-triazine

Solvants

ether

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture is heated to 50° C.
2. 2
   Concentrationconcentrated by evaporation under water jet vaccum
3. 3
   workup.ADDITIONThe dry riesidue is diluted with 500 ml
4. 4
   workup.STIRRINGof water and after stirring for 1 hour at room temperature
5. 5
   Autrethe tiny white crystals formed
6. 6
   Autreare separated
7. 7
   Filtrationby filtering under suction
8. 8
   Autredried under water jet vacuum at 80° C

Mode opératoire

138 g of 2-cyclopropylamino-4,6-dichloro-s-triazine are added at a slightly elevated tmeperature and with vigorous stirring to a mixture of 675 ml of dioxane and 135 ml of ether. After cooling to room temperature, 101 ml of 25%, aqueous ammonia are added dropwise over a period of 20 minutes. The reaction mixture is heated to 50° C., stirred for 16 hours and then concentrated by evaporation under water jet vaccum. The dry riesidue is diluted with 500 ml. of water and after stirring for 1 hour at room temperature, the tiny white crystals formed are separated by filtering under suction and dried under water jet vacuum at 80° C. 217 g. of 2-cyclopropylamino-4-chloro-6-amino-s-triazine are obtained.

Source