Réaction #56319

Équation de réaction

2-Methoxyaniline

sodium carbonate

2-Bromomethyl-4-methyl-5-ethyl-1,3-dioxolane

→

N-(4-methyl-5-ethyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline

Conditions de réaction

Traitement

1. 1
   Autreequipped with a mechanical stirrer
2. 2
   Températurethermometer and reflux condenser
3. 3
   Températurethe reaction mixture is heated
4. 4
   Températureat reflux for a period of about 1 hour
5. 5
   FiltrationAfter this time the reaction mixture is filtered
6. 6
   workup.ADDITIONadditional sodium carbonate (5 grams) is added to the filtrate
7. 7
   workup.DISTILLATIONThe mixture is then distilled under reduced pressure

Mode opératoire

2-Methoxyaniline (0.05 mole) and sodium carbonate (30 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Bromomethyl-4-methyl-5-ethyl-1,3-dioxolane (0.55 mole) is slowly added and the reaction mixture is heated at reflux for a period of about 1 hour. After this time the reaction mixture is filtered and additional sodium carbonate (5 grams) is added to the filtrate. The mixture is then distilled under reduced pressure to yield the desired product N-(4-methyl-5-ethyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline.

Source