Réaction #56159

Équation de réaction

2,6-dichloro-4-phenyl-3-cyano-pyridine

morpholine

→

2-chloro-6-morpholino-4-phenyl-3-cyano-pyridine

Rendement 86.1%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurethe resulting mixture was refluxed for about two hours
2. 2
   TempératureEven while refluxing
3. 3
   Températureprimarily upon subsequent cooling (optionally on an ice water bath) of the reaction mixture
4. 4
   Autrea colorless crystalline precipitate formed which
5. 5
   Filtrationwas collected by suction filtration
6. 6
   Lavagevery thoroughly washed with water
7. 7
   Autredried

Mode opératoire

A suspension of 24.9 gm (0.1 mol) of 2,6-dichloro-4-phenyl-3-cyano-pyridine in 400 ml of ethanol was slowly admixed with 17.4 gm (0.2 mol) of morpholine, and the resulting mixture was refluxed for about two hours. Even while refluxing, but primarily upon subsequent cooling (optionally on an ice water bath) of the reaction mixture, a colorless crystalline precipitate formed which was collected by suction filtration, very thoroughly washed with water and dried. 25.8 gm (86% of theory) of 2-chloro-6-morpholino-4-phenyl-3-cyano-pyridine, m.p. 198°-200° C., were obtained.

Source