Réaction #5610

Équation de réaction

5-benzyloxy-2-vinyl-4-pyridone

pyrrolidine

→

5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

Solvants

tetrahydrofuran

diisopropyl ether

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températurerefluxed for an hour
3. 3
   TempératureThe mixture was cooled
4. 4
   Filtrationthe resulting precipitate was collected by filtration
5. 5
   Lavagewashed with diisopropyl ether
6. 6
   Autreair-dried at ambient temperature

Mode opératoire

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone (3.79 g).

Source