Réaction #56053

Équation de réaction

pyridine

8-hydroxy-5-(α-isopropylaminobutyryl)carbostyril

isobutyryl chloride

→

8-isobutyryloxy-5-(α-Isopropylaminobutyryl)carbostyril hydrochloride

Solvants

diethyl ether

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added dropwise to the mixture
2. 2
   workup.STIRRINGby stirring for 2 hours
3. 3
   Autrethe precipitate formed
4. 4
   Lavagewas washed with diethyl ether
5. 5
   workup.STIRRINGstirred in a small amount of cold water
6. 6
   AutreThe precipitate was separated by filtration
7. 7
   Lavagewashed successively with a small amount of water, acetone and diethyl ether
8. 8
   Autreto obtain a crystalline product which
9. 9
   Autrewas then recrystallized from acetone

Mode opératoire

50 ml of pyridine was added to 2.5 g of 8-hydroxy-5-(α-isopropylaminobutyryl)carbostyril, and 5 ml of isobutyryl chloride was added dropwise to the mixture while cooling with ice-water and stirring followed by stirring for 2 hours. After addition of about 500 ml of diethyl ether, the precipitate formed was washed with diethyl ether and stirred in a small amount of cold water. The precipitate was separated by filtration, washed successively with a small amount of water, acetone and diethyl ether to obtain a crystalline product which was then recrystallized from acetone to obtain 2.1 g of 8-isobutyryloxy-5-(α-Isopropylaminobutyryl)carbostyril hydrochloride having a melting point of 231°-233° C. (with decomposition).

Source