Réaction #56024

Équation de réaction

7-chloro-2,3-dihydro-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile

ethaneperoxoic acid

→

7-chloro-2,3-dihydro-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile 10-oxide

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Filtrationare filtered out
2. 2
   Autredried in air
3. 3
   Autrerecrystallized from aqueous N,N-dimethylformamide

Mode opératoire

A mixture of 1 part of 7-chloro-2,3-dihydro-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile, 14 parts of ethaneperoxoic acid, and 58 parts of acetic acid is stirred at room temperature for 27 hours, whereupon insoluble solids are filtered out, dried in air, and recrystallized from aqueous N,N-dimethylformamide to give 7-chloro-2,3-dihydro-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile 10-oxide as a colorless solid melting above 300°.

Source