Réaction #558527

Équation de réaction

diethyl 2-benzyloxycarbonylaminomalonate

potassium carbonate

potassium iodide

isopropyl 2-bromoacetate

hydrochloric acid

→

title compound

Rendement 102.7%

diethyl 2-benzyloxycarbonylamino-2-(isopropyloxycarbonylmethyl)malonate

Rendement 102.7%

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture was cooled
2. 2
   Extractionthe mixture was extracted with ethyl acetate
3. 3
   Lavagethe extract was washed with saturated brine
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   AutreThe solvent was evaporated under reduced pressure
6. 6
   Autrepurification

Mode opératoire

A suspension of diethyl 2-benzyloxycarbonylaminomalonate (5.0 g), potassium carbonate (2.7 g), potassium iodide (0.32 g), and isopropyl 2-bromoacetate (3.5 g) in DMF (50 mL) was stirred at 50° C. for 1 hour. The reaction mixture was cooled, and then poured into diluted hydrochloric acid, the mixture was extracted with ethyl acetate, and the extract was washed with saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was subjected to silica gel column chromatography, and then purification was performed with n-hexane/ethyl acetate (5:1), to obtain the title compound (6.8 g, yield: 99%) as colorless oil.

Source