Réaction #55652

Équation de réaction

4-(4-Methoxyphenyl)butyraldehyde

cyanoacetic acid

sodium hydroxide

glyme

hydrochloric acid

→

title compound

3-[3-(4-Methoxyphenyl)propyl]glutaric acid

Solvants

water

Conditions de réaction

Mode opératoire

4-(4-Methoxyphenyl)butyraldehyde (5.34 g) is reacted with cyanoacetic acid (5.15 g) and sodium hydroxide (2.74 g) in a mixture of glyme (50 ml) and water (60 ml). The mixture is treated with hydrochloric acid and processed as described in Example 2A to afford the title compound (2.1 g) which on crystallization from ethyl acetate-chloroform-hexane had a melting point of 71°-73° C.

Source