Réaction #55651

ord-e61c9e3f236d43aea02cdb1f6284fdb6

Équation de réaction

O=C(O)CC(CCc1ccc(O)cc1)CC(=O)O
3-[2-(4-hydroxyphenyl)ethyl]glutaric acid
CC(=O)OC(C)=O
acetic anhydride
→
CC(=O)Oc1ccc(CCC2CC(=O)OC(=O)C2)cc1
3-[2-[4-(acetyloxy)phenyl]ethyl]glutaric anhydride

Réactifs

O=C(O)CC(CCc1ccc(O)cc1)CC(=O)O
3-[2-(4-hydroxyphenyl)ethyl]glutaric acid
CC(=O)OC(C)=O
acetic anhydride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreIt is evaporated in vacuo
  2. 2
    Autrethe residue is crystallized from dichloromethane-hexane

Mode opératoire

A solution of 3-[2-(4-hydroxyphenyl)ethyl]glutaric acid (600 mg) in acetic anhydride (15 ml) is heated in a bath at 120° C. for 2.0 hours. It is evaporated in vacuo and the residue is crystallized from dichloromethane-hexane to afford 495 mg of 3-[2-[4-(acetyloxy)phenyl]ethyl]glutaric anhydride, melting point 97°-99° C.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US04221725uspto-grants-1980_09